AMPEROZIDE AND CONDITIONED BEHAVIOR IN RATS - POTENTIATION BY CLASSICAL NEUROLEPTICS AND ALPHA-METHYLPARATYROSINE

被引：17

作者：

EGBE, P ^{[1
]}

ENGEL, J ^{[1
]}

GUSTAFSSON, B ^{[1
]}

CHRISTENSSON, E ^{[1
]}

机构：

[1] PHARMACIA LEO THERAPEUT AB,DEPT CNS RES,S-20180 MALMO,SWEDEN

来源：

PHARMACOLOGY & TOXICOLOGY | 1990年 / 66卷

关键词：

D O I：

10.1111/j.1600-0773.1990.tb01601.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Amperozide, a new putatively antipsychotic compound, has been evaluated for its effect on conditioned avoidance response and food‐reinforced lever‐pressing. Given alone, amperozide was almost equipotent to clozapine, but less potent than haloperidol in both test models. It was found that there was a statistically significant synergism, in these two models, between amperozide and classical neuroleptics. Since amperozide is inactive in behavioural tests reflecting striatal dopaminergic mechanisms, the synergistic effect could be of great therapeutic value in the treatment of psychotic disorders. 1990 Nordic Pharmacological Society

引用

页码：18 / 21

页数：4

共 16 条

[1] INTERACTION BETWEEN PIMOZIDE AND ALPHA-METHYLTYROSINE [J].

AHLENIUS, S ;

ENGEL, J .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1973, 25 (02) :172-174

[2] BEHAVIORAL EFFECTS OF HALOPERIDOL AFTER TYROSINE HYDROXYLASE INHIBITION [J].

AHLENIUS, S ;

ENGEL, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1971, 15 (02) :187-&

[3]

AHLENIUS S, 1977, ACTA PHARMACOL TOX, V40, P115

[4]

ARNT J, 1982, ACTA PHARMACOL TOX, V51, P321

[5] POTENTIATION OF PHENOTHIAZINES BY ALPHA-METHYLTYROSINE IN TREATMENT OF CHRONIC SCHIZOPHRENIA [J].

CARLSSON, A ;

WALINDER, J ;

ROOS, BE ;

PERSSON, T .

JOURNAL OF NEURAL TRANSMISSION, 1972, 33 (02) :83-&

[6] FURTHER STUDIES ON MECHANISM OF ANTIPSYCHOTIC ACTION - POTENTIATION BY ALPHA-METHYLTYROSINE OF THIORIDAZINE EFFECTS IN CHRONIC SCHIZOPHRENICS [J].

CARLSSON, A ;

ROOS, BE ;

WALINDER, J ;

SKOTT, A .

JOURNAL OF NEURAL TRANSMISSION, 1973, 34 (02) :125-132

[7]

CHRISTENSSON EG, 1985, ACTA PHYSIOL SCAND, V124, P281

[8]

CHRISTENSSON EG, 1981, 3RD WORLD C BIOL PSY

[9] EFFECTS OF AMPEROZIDE, A PUTATIVE ANTIPSYCHOTIC DRUG, ON RAT MIDBRAIN DOPAMINE NEURONS RECORDED INVIVO [J].

GRENHOFF, J ;

TUNG, CS ;

UGEDO, L ;

SVENSSON, TH .

PHARMACOLOGY & TOXICOLOGY, 1990, 66 :29-33

[10]

GUSTAFSSON B, 1986, PSYCHOPHARMACOLOGY, V89, pS17

← 1 2 →