Prevention of Adverse Pregnancy Outcomes With Low-Dose ASA in Early Pregnancy: New Perspectives for Future Randomized Trials

被引：9

作者：

Bujold, Emmanuel ^{[1
,2
]}

Tapp, Sylvie ^{[2
,3
]}

Audibert, Francois ^{[4
]}

Ferreira, Ema ^{[5
]}

Forest, Jean-Claude ^{[6
]}

Rey, Evelyne ^{[7
,8
]}

Fraser, William D. ^{[4
]}

Chaillet, Nils ^{[4
]}

Giguere, Yves ^{[6
]}

机构：

[1] Univ Laval, Fac Med, Dept Obstet & Gynecol, Quebec City, PQ, Canada

[2] CRCHUQ, Quebec City, PQ, Canada

[3] Univ Laval, Fac Med, Dept Social & Prevent Med, Quebec City, PQ, Canada

[4] Univ Montreal, Fac Med, CHU Hop St Justine, Dept Obstet & Gynecol, Montreal, PQ, Canada

[5] Univ Montreal, Fac Med, CHU Hop St Justine, Dept Pharm, Montreal, PQ, Canada

[6] Univ Laval, Fac Med, Dept Med Biol, Quebec City, PQ, Canada

[7] Univ Montreal, Fac Med, Dept Med, Montreal, PQ, Canada

[8] Univ Montreal, Fac Med, Dept Obstet & Gynecol, Montreal, PQ, Canada

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA | 2011年 / 33卷 / 05期

基金：

加拿大健康研究院;

关键词：

Pregnancy; acetylsalicylic acid; low-dose ASA; preeclampsia; intrauterine growth restriction; preterm birth;

D O I：

10.1016/S1701-2163(16)34882-4

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Recent evidence suggests that treatment with low-dose acetylsalicylic acid (ASA) started early in pregnancy could prevent preeclampsia and intrauterine growth restriction (IUGR), two complications involving placental dysfunction. Preterm birth could also potentially be prevented, suggesting that it could share mechanisms of disease with preeclampsia and intrauterine growth restriction. Because there is new evidence that placental dysfunction can be predicted as early as in the first trimester, we argue that there is a need for randomized controlled trials of low-dose ASA for the prevention of preeclampsia, IUGR, and possibly preterm birth among nulliparous women with early indicators of placental dysfunction.

引用

收藏

页码：480 / 483

页数：4

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