Cardiovascular Risk Associated With NSAIDs and COX-2 Inhibitors

被引：0

作者：

Perry, Laura A. ^{[1
]}

Mosier, Charles ^{[1
]}

Atkins, Ashton ^{[1
]}

Minehart, Megan ^{[1
]}

机构：

[1] Univ Findlay, Coll Pharm, Findlay, OH 45840 USA

来源：

US PHARMACIST | 2014年 / 39卷 / 03期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat pain associated with a variety of medical conditions. Nonselective NSAIDs reversibly inhibit the enzyme cyclooxygenase (COX) in both of its isoforms, COX-1 and COX-2. An increased risk of cardiovascular events has been associated with the use of NSAIDs, especially of COX-2 selective NSAIDs. Current evidence suggests that naproxen, a nonselective NSAID, is associated with the lowest risk of cardiovascular events. Therefore, naproxen is the NSAID of choice in patients with high cardiovascular risk.

引用

页码：35 / 38

页数：4

共 16 条

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