ROLE OF ADF/TRX AND ITS INHIBITOR ON THE RELEASE OF MAJOR BASIC-PROTEIN FROM HUMAN EOSINOPHILS

被引：8

作者：

KOYANAGI, H

WAKASUGI, N

YOSHIMATSU, K

TAKASHIMA, Y

YODOI, JJ

MOMOI, M

SUDA, T

KASAHARA, T

YAMAGUCHI, Y

机构：

[1] KUMAMOTO UNIV, SCH MED, INST MOLEC EMBRYOL & GENET, DEPT CELL DIFFERENTIAT, KUMAMOTO 860, JAPAN

[2] JICHI MED SCH, DEPT PEDIAT & MED BIOL & PARASITOL, TOCHIGI, JAPAN

[3] BANYU TSUKUBA RES INST, MOLEC BIOL RES LABS, TSUKUBA, IBARAKI, JAPAN

[4] EISAI & CO LTD, TSUKUBA RES LABS, TSUKUBA, IBARAKI 30026, JAPAN

[5] KYOTO UNIV, INST VIRUS RES, KYOTO, JAPAN

[6] KYORITSU COLL PHARMACEUT SCI, DEPT BIOCHEM, TOKYO, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 213卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2245

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adult T cell leukemia-derived factor (ADF)/Thioredoxin (TRX), originally defined as an IL-2 receptor alpha-chain/p55 inducer, has many cytokine-like activities. We reported that the release of major basic protein (MBP) from mature eosinophils stimulated with cytochalasin B and C5a were augmented after preincubation with recombinant ADF/TRX. The addition of a TRX specific inhibitor, BE40644, suppressed the augmentation of MBP release from mature eosinophils. It is suggested that BE40644 is applicable in allergic diseases associated with eosinophils. (C) 1995 Academic Press, Inc.

引用

页码：1140 / 1147

页数：8

共 25 条

[1] EOSINOPHILS AND EOSINOPHIL CATIONIC PROTEIN IN NASAL LAVAGES IN ALLERGEN-INDUCED HYPERRESPONSIVENESS - EFFECTS OF TOPICAL GLUCOCORTICOSTEROID TREATMENT [J].