P300 AMPLITUDE IN NON-BIPOLAR, MELANCHOLIC DEPRESSION

被引：137
作者：
GANGADHAR, BN
ANCY, J
JANAKIRAMAIAH, N
UMAPATHY, C
机构：
[1] Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore
来源：
JOURNAL OF AFFECTIVE DISORDERS | 1993年 / 28卷 / 01期
关键词：
EVENT RELATED POTENTIAL; P300; MELANCHOLIA;
D O I：
10.1016/0165-0327(93)90077-W
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
P300 event related potential (ERP) was recorded using the auditory 'oddball' paradigm in 17 melancholic, drug-free depressive patients and 22 normal controls. Repeat ERP recordings were obtained from 13 patients after recovery with ECT. Pretreatment P300 latencies were not different between patients and controls, nor did they change in the depressives following recovery. Pretreatment P300 amplitudes in depressives were smaller (P < 0.02) than in controls and negatively correlated with severity (P < 0.05). P300 amplitudes significantly increased in patients following recovery (P < 0.05) and normalized. P300 may be a state marker for melancholic depression.
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页码：57 / 60
页数：4
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