BODY-TEMPERATURE INFLUENCES ETHANOL AND ETHANOL PENTOBARBITAL LETHALITY IN MICE

被引：2

作者：

FINN, DA ^{[1
]}

SYAPIN, PJ ^{[1
]}

BEJANIAN, M ^{[1
]}

JONES, BL ^{[1
]}

ALKANA, RL ^{[1
]}

机构：

[1] UNIV SO CALIF,SCH PHARM,ALCOHOL & BRAIN RES LAB,1985 ZONAL AVE,LOS ANGELES,CA 90033

来源：

ALCOHOL | 1991年 / 8卷 / 01期

关键词：

BODY TEMPERATURE; LETHALITY; ETHANOL; PENTOBARBITAL; MICE; DEPENDENCE; TOXICITY;

D O I：

10.1016/0741-8329(91)91232-Q

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The effect of body temperature on ethanol (ETOH) or ethanol plus pentobarbital (ETOH/PB) lethanlity was investigated in C57BL/6J mice. Decreasing ambient temperatures from 35-20 degrees C, decreased rectal temperatures from 38-20 degrees C and increased 8-hour survival from 0-93% for ETOH-treated and from 0-100% for ETOH/PB-treated mice. ETOH and ETOH/PB animals with no hypothermia (body temperatures = 38 degrees C) had the highest lethality. Those with body temperatures between 30-32 degrees C had the highest 24-hour survival. These results suggest that controlled hypothermia may be useful in reducing lethality from ethanol or ethanol/combination overdoses.

引用

页码：39 / 41

页数：3

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