A NEW ROUTE TO 1,5-DISUBSTITUTED 4-ARYLSULFONYLPYRAZOLES BY LITHIATION OF 1-METHYL-4-ARYLSULFONYLPYRAZOLES

被引：7

作者：

HOFFMANN, MG ^{[1
]}

机构：

[1] HOECHST SCHERING AGREVO GMBH,D-65926 FRANKFURT,GERMANY

来源：

TETRAHEDRON | 1995年 / 51卷 / 35期

关键词：

D O I：

10.1016/0040-4020(95)00540-O

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The arylsulfonylvinamidinium salts 1 reacted with hydrazine in refluxing ethanol to give rise to 4-arylsulfonylpyrazoles 2 in reasonable yield. Regioselective lithiation of N-methylpyrazoles 3 with LDA followed by treatment with various electrophiles afforded the corresponding 1,5-disubstituted 4-arylsulfonylpyrazoles 5 in good yield.

引用

页码：9511 / 9518

页数：8

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