BINDING-SITES FOR THE HERPES-SIMPLEX VIRUS IMMEDIATE-EARLY PROTEIN ICP4 IMPOSE AN INCREASED DEPENDENCE ON VIRAL-DNA REPLICATION ON SIMPLE-MODEL PROMOTERS LOCATED IN THE VIRAL GENOME

被引:12
作者
KOOP, KE
DUNCAN, J
SMILEY, JR
机构
[1] MCMASTER UNIV,DEPT BIOL,MOLEC VIROL & IMMUNOL PROGRAMME,1200 MAIN ST W,HAMILTON L8N 3Z5,ONTARIO,CANADA
[2] MCMASTER UNIV,DEPT PATHOL,MOLEC VIROL & IMMUNOL PROGRAMME,HAMILTON L8N 3Z5,ONTARIO,CANADA
关键词
D O I
10.1128/JVI.67.12.7254-7263.1993
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We examined the ability of binding sites for the herpes simplex virus immediate-early protein ICP4 to alter the regulation of closely linked promoters by placing strong ICP4 binding sites upstream or downstream of simple TATA promoters in the intact viral genome. We found that binding sites strongly reduced the levels of expression at early times postinfection and that this effect was partially overcome after the onset of viral DNA replication. These data confirm that DNA-bound ICP4 can inhibit the activity of a closely linked promoter and raise the possibility that ICP4 binding sites contribute to temporal regulation during infection.
引用
收藏
页码:7254 / 7263
页数:10
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