LEUKOTRIENE-D4 - A POTENT CORONARY-ARTERY VASOCONSTRICTOR ASSOCIATED WITH IMPAIRED VENTRICULAR CONTRACTION

被引：254
作者：
MICHELASSI, F
LANDA, L
HILL, RD
LOWENSTEIN, E
WATKINS, WD
PETKAU, AJ
ZAPOL, WM
机构：
[1] HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA
[2] HARVARD UNIV, SCH MED, DEPT ANESTHESIA, BOSTON, MA 02115 USA
[3] MASSACHUSETTS GEN HOSP, SURG SERV, BOSTON, MA 02114 USA
来源：
SCIENCE | 1982年 / 217卷 / 4562期
关键词：
D O I：
10.1126/science.6808665
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Leukotriene D4 (2 .times. 10-9 mol), injected into the left circumflex coronary artery of anesthetized sheep, produced profound coronary vasoconstriction and impaired regional ventricular wall motion. This [anaphylactic] cardiac effect was neither inhibited by prior treatment of the sheep with a cyclooxygenase inhibitor [ibuprofen] nor associated with thromboxane B2 release into the coronary sinus. I.v. FPL 55712 completely abolished the coronary vasoconstriction of leukotriene D4, but a significant reduction of regional wall shortening persisted.
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页码：841 / 843
页数：3
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