SOLID-STATE NMR AND IR FOR THE ANALYSIS OF PHARMACEUTICAL SOLIDS - POLYMORPHS OF FOSINOPRIL SODIUM

被引：45

作者：

BRITTAIN, HG

MORRIS, KR

BUGAY, DE

THAKUR, AB

SERAJUDDIN, ATM

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, New Brunswick, NJ 08903

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 11-12期

基金：

美国国家科学基金会;

关键词：

FOSINOPRIL SODIUM; POLYMORPHISM; INFRARED SPECTROSCOPY; SOLID STATE C-13- AND P-31-NMR; THERMAL ANALYSIS; POWDER X-RAY DIFFRACTION;

D O I：

10.1016/0731-7085(93)80083-D

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The two polymorphic modifications of fosinopril sodium have been characterized as to their differences in melting behaviour, powder X-ray diffraction patterns, Fourier transform infrared spectra (FTIR), and solid-state P-31- and C-13-NMR spectra. The polymorphs were found to be enantiotropically related based upon melting point, heat of fusion, and solution mediated transformation data. Analysis of the solid-state FTIR and C-13-NMR data indicated that the environment of the acetal side chain of fosinopril sodium differed in two polymorphs, and that there might be cis-trans isomerization about the C-6-N peptide bond. These conformational differences are postulated as the origin of the observed polymorphism.

引用

页码：1063 / 1069

页数：7

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