PROTECTIVE EFFECT OF CISAPRIDE AGAINST INDOMETHACIN-INDUCED OBSTRUCTION OF THE GASTRIC-MUCOSAL HEMODYNAMICS IN RATS

被引：2
|
作者：
YOKOYAMA, T [1 ]
KITAZAWA, T [1 ]
ISHII, A [1 ]
OGIHARA, T [1 ]
SATO, N [1 ]
KARASAWA, A [1 ]
机构：
[1] JUNTENDO UNIV, SCH MED, DEPT GASTROENTEROL, BUNKYO KU, TOKYO 113, JAPAN
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1994年 / 65卷 / 02期
关键词：
CISAPRIDE; STOMACH; MUCOSAL BLOOD FLOW;
D O I：
10.1254/jjp.65.171
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the effect of cisapride, a gastroprokinetic agent, on the obstructed gastric mucosal hemodynamics induced by indomethacin using an organ reflectance spectrophotometry system in rats. Indomethacin (10 mg/kg, i.v.) reduced both the gastric mucosal blood volume and the gastric mucosal blood oxygenation. Pretreatment with cisapride (0.1 mg/kg, i.v.) prevented these deteriorations. The presently-clarified gastric mucosal protective effect of cisapride may contribute to its therapeutic efficacy.
引用
收藏
页码：171 / 173
页数：3
相关论文
共 50 条
  • [1] PENTHOXYFILLINE PROTECTS AGAINST INDOMETHACIN-INDUCED ACUTE GASTRIC-MUCOSAL DAMAGE IN RATS
    SANTUCCI, L
    FIORUCCI, S
    GIANSANTI, M
    BRUNORI, P
    MIGLIETTI, C
    MORELLI, A
    GASTROENTEROLOGY, 1993, 104 (04) : A185 - A185
  • [2] ROLE OF NEUTROPHILS IN INDOMETHACIN-INDUCED GASTRIC-MUCOSAL LESIONS IN RATS
    ALICAN, I
    COSKUN, T
    CORAK, A
    YEGEN, BC
    OKTAY, S
    KURTEL, H
    INFLAMMATION RESEARCH, 1995, 44 (04) : 164 - 168
  • [3] Protective effect of taurine on indomethacin-induced gastric mucosal injury
    Son, MW
    Kim, HK
    Kim, WB
    Yang, JN
    Kim, BK
    ARCHIVES OF PHARMACAL RESEARCH, 1996, 19 (02) : 85 - 90
  • [4] Protective effect of taurine on indomethacin-induced gastric mucosal injury
    Son, M
    Kim, HK
    Kim, WB
    Yang, J
    Kim, BK
    TAURINE 2: BASIC AND CLINICAL ASPECTS, 1996, 403 : 147 - 155
  • [5] ROLE OF OXYGEN RADICALS IN INDOMETHACIN-INDUCED GASTRIC-MUCOSAL MICROVASCULAR INJURY IN RATS
    NAITO, Y
    YOSHIKAWA, T
    KANEKO, T
    IINUMA, S
    NISHIMURA, S
    TAKAHASHI, S
    KONDO, M
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 1993, 17 : S99 - S103
  • [6] The Protective Effect of Walnut Oligopeptides against Indomethacin-Induced Gastric Ulcer in Rats
    Liu, Rui
    Zhu, Na
    Hao, Yuntao
    Liu, Xinran
    Kang, Jiawei
    Mao, Ruixue
    Yu, Xiaochen
    Li, Yong
    NUTRIENTS, 2023, 15 (07)
  • [7] Protective effect of roxatidine against indomethacin-induced small intestinal mucosal injury in rats
    Umegaki, Eiji
    Yoda, Yukiko
    Tokioka, Satoshi
    Murano, Mitsuyuki
    Higuchi, Kazuhide
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2010, 25 : S35 - S40
  • [8] PROTECTIVE EFFECT OF LEMINOPRAZOLE, AN ACID PUMP INHIBITOR, ON INDOMETHACIN-INDUCED DAMAGE IN RABBIT GASTRIC-MUCOSAL CELLS
    TAKAHASHI, S
    OKABE, S
    GASTROENTEROLOGY, 1995, 108 (04) : A231 - A231
  • [9] EFFECT OF INDOMETHACIN AND LOXOPROFEN ON HUMAN GASTRIC-MUCOSAL HEMODYNAMICS
    KAWANO, S
    TSUJI, S
    HAYASHI, N
    NAGANO, K
    FUSAMOTO, H
    KAMADA, T
    GASTROENTEROLOGY, 1993, 104 (04) : A115 - A115
  • [10] GASTRIC-MOTILITY IS AN IMPORTANT FACTOR IN THE PATHOGENESIS OF INDOMETHACIN-INDUCED GASTRIC-MUCOSAL LESIONS IN RATS
    UEKI, S
    TAKEUCHI, K
    OKABE, S
    DIGESTIVE DISEASES AND SCIENCES, 1988, 33 (02) : 209 - 216
12345