STUDY OF THE INFLUENCE OF SPHERONIZATION AND DRYING CONDITIONS ON THE PHYSICOMECHANICAL PROPERTIES OF NEUTRAL SPHEROIDS CONTAINING AVICEL PH-101 AND LACTOSE

被引：49

作者：

BATAILLE, B ^{[1
]}

LIGARSKI, K ^{[1
]}

JACOB, M ^{[1
]}

THOMAS, C ^{[1
]}

DURU, C ^{[1
]}

机构：

[1] FAC PHARM DIJON,PHARM GALEN & PHARMACOTECHN LAB,F-21033 DIJON,FRANCE

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1993年 / 19卷 / 06期

关键词：

D O I：

10.3109/03639049309062973

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Beginning with binary Avicel-lactose (20/80) mixtures, the present study focuses on the influence of the spheronization speed and the drying process on the porousness, surface condition and the pressure resistance of neutral spheroids prepared by extrusion/spheronization. Any increase in the spheronization speed provokes a decrease in the porousness and the average diameter of the pores, and gives a greater hardness and a smoother surface condition. In the final production phase, oven drying gives less porous and harder minigranules and a more homogenous surface than those dried by microwaves. In the experiment conditions, a negative correlation between porousness and hardness was established.

引用

页码：653 / 671

页数：19