FACILE SYNTHESIS OF 5-SUBSTITUTED 2-ACETYLTHIOPHENES

被引：0
|
作者：
GODA, H [1 ]
SATO, M [1 ]
IHARA, H [1 ]
HIRAYAMA, C [1 ]
机构：
[1] SUMITOMO SEIKA CHEM CO LTD,RES LAB I,HYOGO 67501,JAPAN
来源：
SYNTHESIS-STUTTGART | 1992年 / 09期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
5-Substituted 2-(alpha-alkoxyimino)ethylthiophenes 4-8 are obtained by the reaction of 2-(alpha-alkoxyimino)ethylthiophenes 3 and electrophilic reagents. Hydrolysis of thiophenes 4-8 produces 5-substituted 2-acetylthiophenes 9-13, respectively. Compounds 3 are easily obtained either by the reaction of 2-acetylthiophene (1) and an O-alkylhydroxylamine or by oxidation of 1 followed by O-alkylation.
引用
收藏
页码：849 / 851
页数：3
相关论文
共 50 条
  • [41] Synthesis of 5-substituted analogues of huperzine A
    Zhou, GC
    Zhu, DY
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (18) : 2055 - 2057
  • [42] AN IMPROVED SYNTHESIS OF 5-SUBSTITUTED TETRAZOLES
    FINNEGAN, WG
    HENRY, RA
    LOFQUIST, R
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (15) : 3908 - 3911
  • [43] SYNTHESIS OF VARIOUS 5-SUBSTITUTED URACILS
    PETERS, D
    HORNFELDT, AB
    GRONOWITZ, S
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1990, 27 (07) : 2165 - 2173
  • [44] Direct synthesis of 5-substituted naphthoquinones
    Kraus, GA
    Kim, J
    JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (07): : 2358 - 2360
  • [45] SYNTHESIS OF 5-SUBSTITUTED AND 3,5-SUBSTITUTED 2-AMINOPYRAZINES BY PD MEDIATED STILLE COUPLING
    NAKAMURA, H
    TAKEUCHI, D
    MURAI, A
    SYNLETT, 1995, (12) : 1227 - &
  • [46] SYNTHESIS OF 5-SUBSTITUTED URACILS, URIDINES, AND 2'-DEOXYURIDINE ANALOGS
    CHERN, JW
    WISE, DS
    BUTLER, W
    TOWNSEND, LB
    JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (24): : 5622 - 5628
  • [47] Synthesis of 5-Substituted 2-Nitraminopyrimidines and 2-Hydroxyaminopyrimidines
    Moskalenko, G. G.
    Shkurko, O. P.
    Chemistry of Heterocyclic Compounds, 33 (07):
  • [48] SYNTHESIS OF SOME 5-SUBSTITUTED SULFINYL-2-FURANCARBALDEHYDES
    SUGDEN, JK
    WILLCOCKS, K
    PHARMACEUTICA ACTA HELVETIAE, 1978, 53 (06): : 170 - 171
  • [49] Synthesis and Transformations of 5-Substituted 2-Furoyl Phosphonates
    L. M. Pevzner
    A. I. Ponyaev
    Russian Journal of General Chemistry, 2019, 89 : 42 - 50
  • [50] SYNTHESIS OF 5-SUBSTITUTED ETHYL PYRROLE-2-CARBOXYLATES
    ELDER, T
    GREGORY, LC
    OROZCO, A
    PFLUG, JL
    WIENS, PS
    WILKINSON, TJ
    SYNTHETIC COMMUNICATIONS, 1989, 19 (5-6) : 763 - 767
12345