DRUG ABSORPTION .2. EFFECT OF FASTING ON INTESTINAL DRUG ABSORPTION

被引:56
作者
DOLUISIO, JT
TAN, GH
BILLUPS, NF
DIAMOND, L
机构
[1] University of Kentucky, College of Pharmacy, Lexington, Kentucky
关键词
Drug absorption–intestinal; Fasting–intestinal effect; Intestinal absorption; drug–fasting effect; Perfused intestine–drug absorption;
D O I
10.1002/jps.2600581007
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The effects of fasting on the intestinal absorption profiles of salicylic acid, barbital, haloperidol, and chlorpromazine were studied in anesthetized rats. The in situ technique employed in this study yielded absorption rate constants which were realistic and comparable to those observed following oral drug administration. The weak acids, barbital and salicylic acid, were found to obey first‐order kinetics throughout the experiments. The highly lipidsoluble weak bases, haloperidol and chlorpromazine, obeyed firstorder kinetics after the first 10 min. of experimentation. No apparent deviation in absorption patterns occurred when fasting periods were less than 20 hr. However, when the period of inanition exceeded 20 hr., absorption rates were found to decrease significantly and the decrease was dependent on the duration of the fasting period. It is possible that the unusual drug absorption patterns noted in these studies could be accounted for by one or more of the various physiological and/or biochemical changes which occur within an organism subjected to conditions of prolonged fasting. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:1200 / +
页数:1
相关论文
共 15 条
[1]  
Achord J L, 1967, Med Times, V95, P441
[2]   INHIBITION OF INTESTINAL EPITHELIAL CELL RENEWAL AND MIGRATION INDUCED BY STARVATION [J].
BROWN, HO ;
LEVINE, ML ;
LIPKIN, M .
AMERICAN JOURNAL OF PHYSIOLOGY, 1963, 205 (05) :868-&
[3]  
DILLER IC, 1946, GROWTH, V10, P331
[4]   DRUG ABSORPTION .I. AN IN SITU RAT GUT TECHNIQUE YIELDING REALISTIC ABSORPTION RATES [J].
DOLUISIO, JT ;
BILLUPS, NF ;
DITTERT, LW ;
SUGITA, ET ;
SWINTOSKY, JV .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1969, 58 (10) :1196-+
[5]   THE EFFECT OF STARVATION ON EPITHELIAL RENEWAL IN THE RAT DUODENUM [J].
HOOPER, CS ;
BLAIR, M .
EXPERIMENTAL CELL RESEARCH, 1958, 14 (01) :175-181
[6]   URINARY EXCRETION OF CATECHOLAMINES IN FASTING OBESE SUBJECTS [J].
JANUSZEWICZ, W ;
SZNAJDER.M ;
WOCIAL, B .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1967, 27 (01) :130-+
[7]  
JU JS, 1959, J NUTR, V68, P633
[8]  
KOLLAR EJ, 1964, ARCH GEN PSYCHIAT, V11, P113
[9]   EFFECTS OF ADRENALECTOMY AND FASTING ON INTESTINAL FUNCTION IN RAT [J].
LEVIN, RJ ;
NEWEY, H ;
SMYTH, DH .
JOURNAL OF PHYSIOLOGY-LONDON, 1965, 177 (01) :58-&
[10]  
OCHSENFAHRT O, 1968, LIFE SCI, V7, P493