The Combined Impact Of Amlodipin And Regular Physical Exercises On Platelet And Inflammatory Markers In Patients With Arterial Hypertension

It is known that lasting existence of arterial hypertension is very dangerous in respect of stroke, myocardial infarction or sudden death coming and development of impaired cardial function. At the same time, the basic mass of cardio-vascular complications at arterial hypertension is connected with the development of arterial thromboses which develop, as a rule, against the background of atherosclerotic alterations in vessels. In the conducted research we estimated the potential of amlodipin therapy impact and its combination with regular physical exercises on risk markers of the development of thrombosis and inflammatory alterations in vascular wall of patients with arterial hypertension. There were examined 78 men with arterial hypertension of the 2nd degree and 28 clinically healthy persons of the second mature age. In our research we registered the aggregation of erythrocytes and platelets, leucocytes' activity, plasma concentration of von Willebrand's Factor and the quantity of adhesive molecules in plasma. One group of patients received amlodipin 10 mg/a day, the second group of patients received its combinations with physical exercises. The repeated examination of patients was conducted in 3 months. There were detected more evident positive alterations of all the accountable indices against the background of amlodipin therapy in the group having physical exercises. In this respect it can be considered that amlodipin intake by persons with arterial hypertension is more preferable against the background of dosed regular physical exercises as in this case it is possible to minimize the evidence of markers, high risk of thrombosis and active course of atherogenesis.