DISTRIBUTION OF ALZHEIMERS-DISEASE AMYLOID A4-GENERATING ENZYMES IN RAT-BRAIN TISSUE

被引：19
作者：
ISHIURA, S
NISHIKAWA, T
TSUKAHARA, T
MOMOI, T
ITO, H
SUZUKI, K
SUGITA, H
机构：
[1] AOYAMA GAKUIN UNIV,TOKYO 150,JAPAN
[2] TOKYO METROPOLITAN INST MED SCI,TOKYO 113,JAPAN
来源：
NEUROSCIENCE LETTERS | 1990年 / 115卷 / 2-3期
关键词：
Alzheimer's disease; Amyloid; Amyloid A4 protein; Distribution; Proteinase; Rat brain;
D O I：
10.1016/0304-3940(90)90477-Q
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To screen for putative amyloid A4-splitting proteinases, model peptide substrates homologous to the N- and C-terminal portions of the A4 protein were synthesized. The N-terminal A4-splitting enzyme activity was found to be higher in the hypothalamus and limbic area, compared with in the cerebral cortex and cerebellum in 2-month-old rat. The activity decreased throughout the brain in 20-month-old rat. On the other hand, the activity of the putative C-terminal A4-splitting enzyme was significantly higher, 1.4-fold, in the hippocampus than in the cerebral cortex in the young rat. The activity also significantly decreased in the brain of 20-month-old rat, but was still higher in the cerebral cortex, hippocampus and cerebellum. © 1990.
引用
收藏
页码：329 / 334
页数：6
相关论文
共 16 条
  • [1] Barrett A.J., 1977, PROTEINASES MAMMALIA, P1
  • [2] ALZHEIMERS-DISEASE - ITS PROTEINS AND GENES
    GLENNER, GG
    [J]. CELL, 1988, 52 (03) : 307 - 308
  • [3] ISOLATION OF 2 FORMS OF THE HIGH-MOLECULAR-MASS SERINE PROTEASE, INGENSIN, FROM PORCINE SKELETAL-MUSCLE
    ISHIURA, S
    SANO, M
    KAMAKURA, K
    SUGITA, H
    [J]. FEBS LETTERS, 1985, 189 (01) : 119 - 123
  • [4] HUMAN SKELETAL-MUSCLE CONTAINS 2 MAJOR AMINOPEPTIDASES - AN ANION-ACTIVATED AMINOPEPTIDASE-B AND AN AMINOPEPTIDASE-M-LIKE ENZYME
    ISHIURA, S
    YAMAMOTO, T
    YAMAMOTO, M
    NOJIMA, M
    AOYAGI, T
    SUGITA, H
    [J]. JOURNAL OF BIOCHEMISTRY, 1987, 102 (05) : 1023 - 1031
  • [5] IDENTIFICATION OF A PUTATIVE AMYLOID A4-GENERATING ENZYME AS A PROLYL ENDOPEPTIDASE
    ISHIURA, S
    TSUKAHARA, T
    TABIRA, T
    SHIMIZU, T
    ARAHATA, K
    SUGITA, H
    [J]. FEBS LETTERS, 1990, 260 (01) : 131 - 134
  • [6] PUTATIVE N-TERMINAL SPLITTING ENZYME OF AMYLOID A4 PEPTIDES IS THE MULTICATALYTIC PROTEINASE, INGENSIN, WHICH IS WIDELY DISTRIBUTED IN MAMMALIAN-CELLS
    ISHIURA, S
    TSUKAHARA, T
    TABIRA, T
    SUGITA, H
    [J]. FEBS LETTERS, 1989, 257 (02) : 388 - 392
  • [7] THE PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID-A4 PROTEIN RESEMBLES A CELL-SURFACE RECEPTOR
    KANG, J
    LEMAIRE, HG
    UNTERBECK, A
    SALBAUM, JM
    MASTERS, CL
    GRZESCHIK, KH
    MULTHAUP, G
    BEYREUTHER, K
    MULLERHILL, B
    [J]. NATURE, 1987, 325 (6106) : 733 - 736
  • [8] NOVEL PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID PROTEIN SHOWS PROTEASE INHIBITORY ACTIVITY
    KITAGUCHI, N
    TAKAHASHI, Y
    TOKUSHIMA, Y
    SHIOJIRI, S
    ITO, H
    [J]. NATURE, 1988, 331 (6156) : 530 - 532
  • [9] AMYLOID PROTEIN-PRECURSOR MESSENGER-RNAS - DIFFERENTIAL EXPRESSION IN ALZHEIMERS-DISEASE
    PALMERT, MR
    GOLDE, TE
    COHEN, ML
    KOVACS, DM
    TANZI, RE
    GUSELLA, JF
    USIAK, MF
    YOUNKIN, LH
    YOUNKIN, SG
    [J]. SCIENCE, 1988, 241 (4869) : 1080 - 1084
  • [10] AMYLOID A4 PROTEIN AND ITS PRECURSOR IN DOWNS-SYNDROME AND ALZHEIMERS-DISEASE
    RUMBLE, B
    RETALLACK, R
    HILBICH, C
    SIMMS, G
    MULTHAUP, G
    MARTINS, R
    HOCKEY, A
    MONTGOMERY, P
    BEYREUTHER, K
    MASTERS, CL
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (22) : 1446 - 1452
12