ALTERATION OF VOLTAGE-DEPENDENCE OF SHAKER POTASSIUM CHANNEL BY MUTATIONS IN THE S4-SEQUENCE

被引：451
作者：
PAPAZIAN, DM
TIMPE, LC
JAN, YN
JAN, LY
机构：
[1] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,SAN FRANCISCO,CA 94143
来源：
NATURE | 1991年 / 349卷 / 6307期
关键词：
D O I：
10.1038/349305a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.
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页码：305 / 310
页数：6
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