IN-VIVO PROTON MAGNETIC-RESONANCE SPECTROSCOPY DETECTION OF HUMAN ALCOHOL TOLERANCE

被引：20
作者：
CHIU, TM
MENDELSON, JH
WOODS, BT
TEOH, SK
LEVISOHN, L
MELLO, NK
机构：
[1] HARVARD UNIV,MCLEAN HOSP,SCH MED,DEPT NEUROL,ALCOHOL & DRUG ABUSE RES CTR,BELMONT,MA 02178
[2] HARVARD UNIV,MCLEAN HOSP,SCH MED,CTR BRAIN IMAGING,BELMONT,MA 02178
来源：
MAGNETIC RESONANCE IN MEDICINE | 1994年 / 32卷 / 04期
关键词：
ETHANOL; BRAIN; TOLERANCE; MRS;
D O I：
10.1002/mrm.1910320414
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Alcohol tolerance was ascertained with in vivo proton magnetic resonance spectroscopy (MRS) in men who regularly consumed either large (10-20 drinks/week) or small (2-4 drinks/week) amounts of beverage alcohol. Brain ethanol concentrations were determined by MRS, and blood ethanol levels were measured by gas chromatography after controlled ethanol administration (0.8 g/kg). Brain-blood ethanol concentration ratios for heavy drinkers were significantly greater than ratios for occasional drinkers (P < 0.002). Inasmuch as ethanol tolerance covaries with the severity of dependence, MRS procedures may facilitate our understanding of alcohol tolerance and treatment of alcoholism.
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页码：511 / 516
页数：6
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