CHOLINERGIC REGULATION OF ETHANOL-CONSUMPTION IN RATS

被引：0
|
作者：
SPRAGUE, JE [1 ]
SHARP, D [1 ]
MAICKEL, RP [1 ]
机构：
[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT PHARMACOL & TOXICOL,W LAFAYETTE,IN 47907
来源：
RESEARCH COMMUNICATIONS IN SUBSTANCES OF ABUSE | 1994年 / 15卷 / 1-2期
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中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Cholinergic regulation of ethanol consumption was studied in rats using subcutaneous doses of saline, atropine (5 mg/kg), or methylatropine (5 mg/kg) twice daily for two days. Utilizing a two-bottle free-choice paradigm, rats were offered a choice between a 0.2% saccharin solution and a 10% ethanol/0.2% saccharin solution. Methylatropine significantly decreased both ethanol and total fluid consumption on the first day of treatment and depressed only ethanol consumption for the next four days. Atropine significantly decreased only ethanol consumption on both treatment days. These results suggest a peripheral site of action for anticholinergic effects on ethanol consumption
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页码：1 / 8
页数：8
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