Mechanisms of ectopic calcification: implications for diabetic vasculopathy

被引：29

作者：

Avogaro, Angelo ^{[1
,2
]}

Fadini, Gian Paolo ^{[1
,2
]}

机构：

[1] Univ Padua, Dept Med, Div Metab Dis, Padua, Italy

[2] Venetian Inst Mol Med, Lab Expt Diabetol, Padua, Italy

来源：

CARDIOVASCULAR DIAGNOSIS AND THERAPY | 2015年 / 5卷 / 05期

关键词：

Bone; vascular; differentiation; risk factors;

D O I：

10.3978/j.issn.2223-3652.2015.06.05

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vascular calcification (VC) is the deposition of calcium/phosphate in the vasculature, which portends a worse clinical outcome and predicts major adverse cardiovascular events. VC is an active process initiated and regulated via a variety of molecular signalling pathways. There are mainly two types of calcifications: the media VC and the intima VC. All major risk factors for cardiovascular disease (CVD) have been linked to the presence/development of VC. Besides the risk factors, a genetic component is also operative to determine arterial calcification. Several events take place before VC is established, including inflammation, trans-differentiation of vascular cells and homing of circulating pro-calcific cells. Diabetes is an important predisposing factor for VC. Compared with non-diabetic subjects, patients with diabetes show increased VC and higher expression of bone-related proteins in the medial layer of the vessels. In this review we will highlight the mechanisms underlying vascular calcification in diabetic patients.

引用

页码：343 / 352

页数：10

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