SEGREGATION OF RECESSIVE PHENOTYPES IN SOMATIC-CELL HYBRIDS - ROLE OF MITOTIC RECOMBINATION, GENE INACTIVATION, AND CHROMOSOME NONDISJUNCTION

被引：52
作者：
CAMPBELL, CE
WORTON, RG
机构：
[1] HOSP SICK CHILDREN,INST RES,TORONTO M5G 1X8,ONTARIO,CANADA
[2] HOSP SICK CHILDREN,DEPT GENET,TORONTO M5G 1X8,ONTARIO,CANADA
[3] UNIV TORONTO,DEPT MED GENET,TORONTO M5S 1A1,ONTARIO,CANADA
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1981年 / 1卷 / 04期
关键词：
D O I：
10.1128/MCB.1.4.336
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：336 / 346
页数：11
相关论文
共 36 条
[1]   REVERSIBLE INACTIVATION OF AUTOSOMAL ALLELES IN CHINESE-HAMSTER CELLS [J].
BRADLEY, WEC .
JOURNAL OF CELLULAR PHYSIOLOGY, 1979, 101 (02) :325-340
[2]   LINKAGE OF GENETIC-MARKERS EMT AND CHR IN CHINESE-HAMSTER CELLS [J].
CAMPBELL, CE ;
WORTON, RG .
SOMATIC CELL GENETICS, 1980, 6 (02) :215-224
[3]   EVIDENCE OBTAINED BY INDUCED MUTATION FREQUENCY-ANALYSIS FOR FUNCTIONAL HEMIZYGOSITY AT THE EMT LOCUS IN CHO CELLS [J].
CAMPBELL, CE ;
WORTON, RG .
SOMATIC CELL GENETICS, 1979, 5 (01) :51-65
[4]   NON-LINKAGE OF INDUCED MUTATIONS IN CHINESE-HAMSTER CELLS [J].
CHASIN, LA .
NATURE-NEW BIOLOGY, 1972, 240 (97) :50-+
[5]   CHROMOSOMES OF CHO, AN ANEUPLOID CHINESE-HAMSTER CELL LINE - G-BAND, C-BAND, AND AUTORADIOGRAPHIC ANALYSES [J].
DEAVEN, LL ;
PETERSEN, DF .
CHROMOSOMA, 1973, 41 (02) :129-144
[6]   CHROMOSOME LOSS IS RESPONSIBLE FOR SEGREGATION AT HPRT LOCUS IN CHINESE-HAMSTER CELL HYBRIDS [J].
FARRELL, SA ;
WORTON, RG .
SOMATIC CELL GENETICS, 1977, 3 (05) :539-551
[7]   ISOLATION AND PARTIAL CHARACTERIZATION OF 3 METHOTREXATE-RESISTANT PHENOTYPES FROM CHINESE-HAMSTER OVARY CELLS [J].
FLINTOFF, WF ;
DAVIDSON, SV ;
SIMINOVITCH, L .
SOMATIC CELL GENETICS, 1976, 2 (03) :245-261
[8]   ISOLATION AND PRELIMINARY CHARACTERIZATION OF SOMATIC-CELL MUTANTS RESISTANT TO PROTEIN-SYNTHESIS INHIBITOR-EMETINE [J].
GUPTA, RS ;
SIMINOVITCH, L .
CELL, 1976, 9 (02) :213-219
[9]   SEGREGATION STUDIES IN CHO HYBRID-CELLS .1. SPONTANEOUS AND MUTAGEN-INDUCED SEGREGATION EVENTS OF 2 RECESSIVE DRUG-RESISTANT LOCI [J].
HARRIS, JF ;
WHITMORE, GF .
SOMATIC CELL GENETICS, 1977, 3 (02) :173-193
[10]   NON-MENDELIAN SEGREGATION IN HYBRIDS BETWEEN CHINESE-HAMSTER CELLS [J].
HARRIS, M .
JOURNAL OF CELLULAR PHYSIOLOGY, 1975, 86 (02) :413-430
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