Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia

被引：20

作者：

Adler, David H. ^{[1
]}

Wallace, Melissa ^{[2
]}

Bennie, Thola ^{[2
]}

Abar, Beau ^{[1
]}

Meiring, Tracy L. ^{[3
,4
]}

Williamson, Anna-Lise ^{[3
,4
,5
]}

Bekker, Linda-Gail ^{[2
]}

机构：

[1] Univ Rochester, Dept Emergency Med, 601 Elmwood Ave, Rochester, NY 14642 USA

[2] Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, Desmond Tutu HIV Ctr, Anzio Rd, ZA-7925 Cape Town, South Africa

[3] Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, Anzio Rd, ZA-7925 Cape Town, South Africa

[4] Univ Cape Town, Fac Hlth Sci, Div Med Virol, Anzio Rd, ZA-7925 Cape Town, South Africa

[5] Groote Schuur Hosp, Natl Hlth Lab Serv, ZA-7925 Cape Town, South Africa

来源：

ADVANCES IN VIROLOGY | 2016年 / 2016卷

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1155/2016/7310894

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Infection with HIV is known to increase the risk of cervical cancer. In addition, evidence suggests that concurrent infection with multiple human papillomavirus (HPV) genotypes increases the risk of cervical dysplasia more than infection with a single HPV genotype. However, the impact of the combination of HIV coinfection and presence of multiple concurrent HPV infections on the risk of cervical dysplasia is uncertain. We compared the results of HPV testing and Pap smears between HIV-infected and HIV-uninfected young women to assess the cumulative impact of these two conditions. We found that both HIV and the presence of multiple concurrent HPV infections are associated with increased risk of associated Pap smear abnormality and that the impact of these two risk factors may be additive.

引用

页数：5

共 22 条

[1]

Adler DH, 2014, INFECT DIS OBSTET GY, V2014, DOI DOI 10.1155/2014/498048

[2]

Bosch FX, 2013, VACCINE, V31, pF1, DOI [10.1016/j.vaccine.2013.10.001, 10.1016/j.vaccine.2013.07.026, 10.1016/j.vaccine.2013.10.003]

[3] The causal relation between human papillomavirus and cervical cancer [J].

Bosch, FX ;

Lorincz, A ;

Muñoz, N ;

Meijer, CJLM ;

Shah, KV .

JOURNAL OF CLINICAL PATHOLOGY, 2002, 55 (04) :244-265

[4]

BOUVARD V, 2009, LANCET ONCOL, V10, P321, DOI [DOI 10.1016/S1470-2045(09)70096-8, 10.1016/s1470-2045(09)70096-8]

[5] Persistence of Concurrent Infections with Multiple Human Papillomavirus Types: A Population-based Cohort Study [J].

Campos, Nicole G. ;

Cecilia Rodriguez, Ana ;

Castle, Philip E. ;

Herrero, Rolando ;

Hildesheim, Allan ;

Katki, Hormuzd ;

Kim, Jane J. ;

Wacholder, Sholom ;

Morales, Jorge ;

Burk, Robert D. ;

Schiffman, Mark .

JOURNAL OF INFECTIOUS DISEASES, 2011, 203 (06) :823-827

[6] Human papillomavirus types among women infected with HIV:: a meta-analysis [J].

Clifford, Gary M. ;

Goncalves, Maria Alice G. ;

Franceschi, Silvia .

AIDS, 2006, 20 (18) :2337-2344

[7] Immunodeficiency and the risk of cervical intraepithelial neoplasia 2/3 and cervical cancer: A nested case-control study in the Swiss HIV cohort study [J].

Clifford, Gary M. ;

Franceschi, Silvia ;

Keiser, Olivia ;

Schoeni-Affolter, Franziska ;

Lise, Mauro ;

Dehler, Silvia ;

Levi, Fabio ;

Mousavi, Mohsen ;

Bouchardy, Christine ;

Wolfensberger, Aline ;

Darling, Katharine E. ;

Staehelin, Cornelia ;

Bertisch, Barbara ;

Kuenzli, Esther ;

Bernasconi, Enos ;

Pawlita, Michael ;

Egger, Matthias .

INTERNATIONAL JOURNAL OF CANCER, 2016, 138 (07) :1732-1740

[8] Cervical Infections by Multiple Human Papillomavirus (HPV) Genotypes: Prevalence and Impact on the Risk of Precancerous Epithelial Lesions [J].

Dal Bello, Barbara ;

Spinillo, Arsenio ;

Alberizzi, Paola ;

Cesari, Stefania ;

Gardella, Barbara ;

D'Ambrosio, Gioacchino ;

Roccio, Marianna ;

Silini, Enrico Maria .

JOURNAL OF MEDICAL VIROLOGY, 2009, 81 (04) :703-712

[9] Human Papillomavirus, Human Immunodeficiency Virus and Immunosuppression [J].

Denny, Lynette A. ;

Franceschi, Silvia ;

de Sanjose, Silvia ;

Heard, Isabelle ;

Moscicki, Anna Barbara ;

Palefsky, Joel .

VACCINE, 2012, 30 :F168-F174

[10] PERSISTENT GENITAL HUMAN PAPILLOMAVIRUS INFECTION AS A RISK FACTOR FOR PERSISTENT CERVICAL DYSPLASIA [J].

HO, GYF ;

BURK, RD ;

KLEIN, S ;

KADISH, AS ;

CHANG, CJ ;

PALAN, P ;

BASU, J ;

TACHEZY, R ;

LEWIS, R ;

ROMNEY, S .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (18) :1365-1371

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