L-2-AMINO-4-PHOSPHONOBUTYRATE (L-AP4) IS AN AGONIST AT THE TYPE-IV METABOTROPIC GLUTAMATE RECEPTOR WHICH IS NEGATIVELY COUPLED TO ADENYLATE-CYCLASE

被引：139

作者：

THOMSEN, C

KRISTENSEN, P

MULVIHILL, E

HALDEMAN, B

SUZDAK, PD

机构：

[1] NOVO NORDISK AS,DEPT RECEPTOR NEUROCHEM CENT NERVOUS SYST DISCOVERY,NORDISK PK,DK-2760 MALOV,DENMARK

[2] NOVO NORDISK AS,DEPT PATHOL & HISTOCHEM PHARMACEUT RES,DK-2760 MALOV,DENMARK

[3] ZYMOGENET,SEATTLE,WA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 227卷 / 03期

关键词：

METABOTROPIC GLUTAMATE RECEPTORS; L-2-AMINO-4-PHOSPHONOBUTYRATE (L-AP4); CAMP;

D O I：

10.1016/0922-4106(92)90018-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glutamate and L-AP4 inhibited forskolin-stimulated cyclic AMP (cAMP) production in baby hamster kidney (BHK) cells transfected with the type IV metabotropic receptor (mGluR4). In situ hybridization revealed a high level of mRNA for the mGluR4 in the entorhinal cortex, but not in the dentate gyrus. These data demonstrate that mGluR4 receptors are negatively coupled to the cAMP cascade, and suggest that the mGluR4 receptor may be the previously described presynaptic L-AP4 receptor.

引用

页码：361 / 362

页数：2

共 8 条

[1]

ABE T, 1992, J BIOL CHEM, V267, P13361

[2] CHARACTERIZATION OF L-2-AMINO-4-PHOSPHONOBUTANOATE ACTION FOLLOWING SENSITIZATION BY QUISQUALATE IN RAT HIPPOCAMPAL SLICE CULTURES [J].