HIGHLY REGIO AND CHEMOSELECTIVE RING-OPENING OF EPOXIDES WITH TRIMETHYLSILYL AZIDE IN THE PRESENCE OF ALUMINUM ISOPROPOXIDE AND TITANIUM ISOPROPOXIDE

被引：50

作者：

SUTOWARDOYO, KI ^{[1
]}

EMZIANE, M ^{[1
]}

LHOSTE, P ^{[1
]}

SINOU, D ^{[1
]}

机构：

[1] UNIV LYON 1,SYNTHESE ASYMET LAB,CNRS,43 BLVD 11 NOVEMBRE 1918,F-69622 VILLEURBANNE,FRANCE

来源：

TETRAHEDRON | 1991年 / 47卷 / 08期

关键词：

D O I：

10.1016/S0040-4020(01)86420-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ring-opening of functionalized epoxides with trimethylsilyl azide in the presence of a catalytic amount of Ti(O-i-Pr)4 or Al(O-i-Pr)3 is described. The reaction is stereospecific and highly regiospecific, leading generally to the formation of the carbon-azido bond on the less substituted carbon. The mechanism of this reaction is also discussed.

引用

页码：1435 / 1446

页数：12

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