NEW INVITRO METHOD FOR TESTING-PLANT METABOLISM IN MUTAGENICITY STUDIES

被引：36

作者：

BENIGNI, R ^{[1
]}

BIGNAMI, M ^{[1
]}

CAMONI, I ^{[1
]}

CARERE, A ^{[1
]}

CONTI, G ^{[1
]}

IACHETTA, R ^{[1
]}

MORPURGO, G ^{[1
]}

ORTALI, VA ^{[1
]}

机构：

[1] IST SUPER SANITA,VIALE REGINA ELENA 299,I-00161 ROME,ITALY

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1979年 / 5卷 / 05期

关键词：

D O I：

10.1080/15287397909529791

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A rapid method was proposed to detect whether a harmless agricultural chemical can be converted into a mutagenic one by plant metabolism. The method is based on the use of Nicotiana alata cell cultures. Results obtained with five pesticides (atrazine, dichlorvos, tetrachlorvinphos, Kelevan, and maleic hydrazide) suggest that the proposed method simulates the metabolism of the whole plant. This procedure was also successfully applied to the genetic system of Aspergillus nidulans. One pesticide, atrazine, induced mutations and somatic segregation only after metabolism during cocultivation with N. alata cells. © 1979 by Hemisphere Publishing Corporation.

引用

页码：809 / 819

页数：11

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