CHROMOSOMAL-ABERRATIONS, SISTER CHROMATID EXCHANGES, AND URINARY THIOETHERS IN NURSES HANDLING ANTINEOPLASTIC DRUGS

被引：25
|
作者：
SARTO, F [1 ]
TREVISAN, A [1 ]
TOMANIN, R [1 ]
CANOVA, A [1 ]
FIORENTINO, M [1 ]
机构：
[1] DIV ONCOL MED,PADUA,ITALY
来源：
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE | 1990年 / 18卷 / 06期
关键词：
biological markers; mercapturic acid; occupational exposures; SCE;
D O I：
10.1002/ajim.4700180607
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
In this study we examined the structural chromosomal aberrations (CA) and sister chromatid exchanges (SCE) of 12 nurses handling moderate quantities of antineoplastic drugs. Urinary thioethers were also measured to assess the potential exposure to alkyl‐ating drugs. Two control groups with similar mean age and smoking habits and working in the same hospital were also studied: 1) control clerks and 2) control nurses. Our study did not show any clear increase of chromosomal damage in exposed nurses as compared to controls. However, CA in control nurses were significantly increased (p = 0.05) with respect to control clerks. The results of baseline urinary excretion of thioethers were statistically higher (p < 0.02) in exposed subjects than in control clerks. Copyright © 1990 Wiley Periodicals, Inc., A Wiley Company
引用
收藏
页码：689 / 695
页数：7
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