LONG-TERM EVALUATION OF ONCE DAILY VIGABATRIN IN DRUG-RESISTANT PARTIAL EPILEPSY

被引：20

作者：

BENMENACHEM, E ^{[1
]}

PERSSON, L ^{[1
]}

MUMFORD, J ^{[1
]}

机构：

[1] MERRELL DOW RES INST,WINNERSH,BERKS,ENGLAND

来源：

EPILEPSY RESEARCH | 1990年 / 5卷 / 03期

关键词：

Long-term study; Once daily dosing; Resistant epilepsy; Vigabatrin;

D O I：

10.1016/0920-1211(90)90045-W

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The purpose of this study was to evaluate on an open basis the long-term efficacy and safety of vigabatrin in drug-resistant partial epilepsy as add-on therapy, administered on a once daily basis. Thirty-five patients entered the study. Twenty patients (57%) responded to therapy and are still on drug. This efficacy is in agreement with that seen in double-blind controlled studies on twice daily dose schedules. There did not appear to be any loss of efficacy with continued treatment at this dose regimen in patients responding favourably to the drug. The once daily dosing schedule was well tolerated and side effects were usually mild and always reversible. Vigabatrin seems to be a valuable therapeutic addition for patients with partial seizures resistant to standard anti-epileptic drugs. © 1990.

引用

页码：240 / 246

页数：7

共 24 条

[1]

BENMENACHEM E, 1986, EPILEPSIA, V27, P649

[2]

BENMENACHEM E, 1988, EPILEPSY RES, V2, P96

[3]

BENMENACHEM E, 1987, BR J CLIN PHARM S1, V27, pS79

[4] VIGABATRIN FOR REFRACTORY COMPLEX PARTIAL SEIZURES - MULTICENTER SINGLE-BLIND STUDY WITH LONG-TERM FOLLOW-UP [J].