ASSOCIATION BETWEEN CLOZAPINE RESPONSE AND ALLELIC VARIATION IN 5HT(2A) RECEPTOR GENE

被引：291

作者：

ARRANZ, M

COLLIER, D

SODHI, M

BALL, D

ROBERTS, G

PRICE, J

SHAM, P

KERWIN, R

机构：

[1] INST PSYCHIAT,NEUROPSYCHOPHARMACOL SECT,LONDON SE5 8AF,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT MOLEC NEUROPATHOL,HARLOW CM19 5AD,ESSEX,ENGLAND

来源：

LANCET | 1995年 / 346卷 / 8970期

关键词：

D O I：

10.1016/S0140-6736(95)92168-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report allelic association between a polymorphism (T102C) within the coding region of the 5-HT2A gene (HTR2A, 13q14-21) and response to clozapine in schizophrenic patients. Homozygosity for the C102 allele was more frequent (30/57, 53%) among patients who did not respond to clozapine than in those who responded (23/92, 25%). This finding is evidence that allelic variation of genes which encode neurotransmitter receptors can influence clinical response to antipsychotic drugs.

引用

页码：281 / 282

页数：2

共 6 条

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[2]

LEYSEN JE, 1994, J CLIN PSYCHIAT, V55, P5

[3] CLOZAPINE, SINGLE PHOTON-EMISSION TOMOGRAPHY, AND THE D2 DOPAMINE RECEPTOR BLOCKADE HYPOTHESIS OF SCHIZOPHRENIA [J].