NONSTEROIDAL ANTIINFLAMMATORY AGENTS - SYNTHESIS AND ENZYME-INHIBITION OF 2-[4-(HETEROARYLMETHYL)PHENYL] PROPANOIC ACIDS AND ANALOGS

被引：0

作者：

SILVESTRI, R ^{[1
]}

PAGNOZZI, E ^{[1
]}

VALOTI, M ^{[1
]}

FUSI, F ^{[1
]}

机构：

[1] UNIV SIENA,IST POLICATTEDRA SCI FARMACOL,I-53100 SIENA,ITALY

来源：

FARMACO | 1994年 / 49卷 / 10期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Some 2-[4-(heteroarylmethyl)phenyl] propanoic acids and phenylacetic and benzoic analogues has been synthesized. All above acids were tested for their inhibitory activity on lipoxygenase and cyclooxygenase, in comparison with NDGA and tolmetin. 2-[4-(Thien-2-ylmethyl)phenyl] propanoic acid 2, strictly related with suprofen, was found the most interesting compund, giving rise to a 79% inhibiton of the cyclooxygenase activity at 10(-4)M concentration.

引用

页码：625 / 632

页数：8

共 14 条

[1] AROMATIC HYDRAZIDES AS SPECIFIC INHIBITORS OF BOVINE SERUM AMINE OXIDASE [J].