EFFECTS OF INTERFERON ON SENSITIVE AND RESISTANT L1210 CELL-LINES

被引：19

作者：

MARTI, J

VANDENBUSSCHE, P

SILHOL, M

MILHAUD, P

VERHAEGEN, M

CONTENT, J

LEBLEU, B

机构：

[1] INST PASTEUR BRABANT, BIOCHIM DES PROT LAB, B-1040 BRUSSELS, BELGIUM

[2] INST PASTEUR BRABANT, DEPT VIROL, B-1040 BRUSSELS, BELGIUM

[3] UNIV MONTPELLIER 2, BIOL MOLEC LAB, F-34060 MONTPELLIER, FRANCE

来源：

JOURNAL OF INTERFERON RESEARCH | 1981年 / 1卷 / 02期

关键词：

D O I：

10.1089/jir.1981.1.287

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

L1210 [mouse leukemia] cells resistant to the antiviral and anticellular effects of interferon [IFN] are not inducible for the 2,5A [2'',5''-oligoadenylate] synthetase and for the protein kinase activities. Cloning of 1 resistant L1210 strain revealed heterogeneity of the cell population with respect to the antiviral and anticellular response as well as protein kinase and 2,5A synthetase inducibility. The defect in the response of truly IFN-resistant L1210 cells appears to reside at an early step of IFN action.

引用

页码：287 / 295

页数：9

共 15 条

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