THE ANTICLASTOGENIC EFFECT OF TOCOPHEROL IN PERITONEAL-MACROPHAGES OF BENZNIDAZOLE-TREATED AND OVARIECTOMIZED MICE

被引：19
作者：
LACAVA, ZGM
LUNA, H
机构：
[1] Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, 70910-900 Brasilia, DF
来源：
MUTATION RESEARCH | 1994年 / 305卷 / 02期
关键词：
BENZNIDAZOLE; CYTOGENETIC DAMAGE; ANTICLASTOGENIC EFFECT; MACROPHAGE; OVARIECTOMY;
D O I：
10.1016/0027-5107(94)90233-X
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Cytogenetic studies revealed a significant increase in the frequency of structural chromosome aberrations of peritoneal macrophages from hyperimmune Swiss mice after ovariectomy. The administration of the nitroarene benznidazole caused a large number of chromosomal deletions in peritoneal macrophages of sham-ovariectomized animals. The clastogenic effect of benznidazole was much greater in peritoneal macrophages of ovariectomized mice. The anti-oxidant alpha-tocopherol protected the peritoneal macrophages from developing ovariectomy- or benznidazole-induced chromosomal aberrations, thus suggesting free radical damage in these processes.
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收藏
页码：145 / 150
页数：6
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