POLYTHEONAMIDES, UNPRECEDENTED HIGHLY CYTOTOXIC POLYPEPTIDES, FROM THE MARINE SPONGE THEONELLA-SWINHOEI .1. ISOLATION AND COMPONENT AMINO-ACIDS

被引：57

作者：

HAMADA, T ^{[1
]}

SUGAWARA, T ^{[1
]}

MATSUNAGA, S ^{[1
]}

FUSETANI, N ^{[1
]}

机构：

[1] UNIV TOKYO, FAC AGR, MARINE BIOCHEM LAB, TOKYO 113, JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(00)75799-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly cytotoxic polypeptides, polytheonamides A-C, have been isolated from the marine sponge Theonella swinhoei. Interpretation of the 2D NMR data of the acid hydrolyzate of polytheonamide B as well as amino acid analysis led to identification of Ala, Asp, Thr, aThr, Ser, Glu, Val, Gly, Ile, t-Leu,beta-methylGlu,beta-methyille,beta-hydroxyVal, and beta-hydroxyAsp. 2D NMR data of polytheonamide B suggested the presence of gamma-hydroxy-t-leu, which was a new amino acid.

引用

页码：719 / 720

页数：2

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