Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection

被引：6

作者：

Boyd, McKenna E. ^{[1
]}

Dao, Harry ^{[2
]}

Estep, Jerry D. ^{[3
]}

Huttenbach, Yve T. ^{[4
]}

Hemmige, Vagish ^{[5
]}

机构：

[1] Baylor Coll Med, 1 Baylor Plaza, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Dermatol, 1977 Butler Blvd, Houston, TX 77030 USA

[3] Cleveland Clin, Dept Cardiol, 9500 Euclid Ave, Cleveland, OH 44195 USA

[4] Baylor Coll Med, Dept Pathol, 1 Baylor Plaza, Houston, TX 77030 USA

[5] Montefiore Med Ctr, Dept Infect Dis, 111 East 210th St, Bronx, NY 10467 USA

来源：

MEDICAL MYCOLOGY CASE REPORTS | 2018年 / 22卷

关键词：

Cutaneous Scedosporium apiospermum; Voriconazole; Trough; Transplant; Immunocompromised;

D O I：

10.1016/j.mmcr.2018.09.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved.

引用

页码：52 / 54

页数：3

共 15 条

[11]

Ogata Ryo, 2011, Nihon Kokyuki Gakkai Zasshi, V49, P388

[12] Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomes [J].

Pascual, Andres ;

Calandra, Thierry ;

Bolay, Saskia ;

Buclin, Thierry ;

Bille, Jacques ;

Marchetti, Oscar .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (02) :201-211

[13] Primary cutaneous infection with Scedosporium apiospermum successfully treated with voriconazole [J].

Stur-Hofmann, K. ;

Stos, S. ;

Saxa-Enenkel, M. ;

Rappersberger, K. .

MYCOSES, 2011, 54 (04) :E201-E204

[14] Treatment of scedosporiosis with voriconazole: Clinical experience with 107 patients [J].

Troke, Peter ;

Aguirrebengoa, Koldo ;

Arteaga, Carmen ;

Ellis, David ;

Heath, Christopher H. ;

Lutsar, Irja ;

Rovira, Montserrat ;

Nguyen, Quoc ;

Slavin, Monica ;

Chen, Sharon C. A. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (05) :1743-1750

[15] Cutaneous Scedosporium apiospermum infection in an immunocompromised patient and a review of the literature [J].

Uenotsuchi, T ;

Moroi, Y ;

Urabe, K ;

Tsuji, G ;

Koga, T ;

Matsuda, T ;

Furue, M .

ACTA DERMATO-VENEREOLOGICA, 2005, 85 (02) :156-159

← 1 2 →