Utilization of voriconazole drug monitoring in the treatment of cutaneous Scedosporium apiospermum infection

被引：6

作者：

Boyd, McKenna E. ^{[1
]}

Dao, Harry ^{[2
]}

Estep, Jerry D. ^{[3
]}

Huttenbach, Yve T. ^{[4
]}

Hemmige, Vagish ^{[5
]}

机构：

[1] Baylor Coll Med, 1 Baylor Plaza, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Dermatol, 1977 Butler Blvd, Houston, TX 77030 USA

[3] Cleveland Clin, Dept Cardiol, 9500 Euclid Ave, Cleveland, OH 44195 USA

[4] Baylor Coll Med, Dept Pathol, 1 Baylor Plaza, Houston, TX 77030 USA

[5] Montefiore Med Ctr, Dept Infect Dis, 111 East 210th St, Bronx, NY 10467 USA

来源：

MEDICAL MYCOLOGY CASE REPORTS | 2018年 / 22卷

关键词：

Cutaneous Scedosporium apiospermum; Voriconazole; Trough; Transplant; Immunocompromised;

D O I：

10.1016/j.mmcr.2018.09.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved.

引用

页码：52 / 54

页数：3

共 15 条

[1] Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans and Scedosporium apiospermum [J].

Cuenca-Estrella, M ;

Ruiz-Díez, B ;

Martínez-Suárez, JV ;

Monzón, A ;

Rodríguez-Tudela, JL .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 43 (01) :149-151

[2] Molecular phylogeny of the Pseudallescheria boydii species complex:: Proposal of two new species [J].

Gilgado, F ;

Cano, J ;

Gené, J ;

Guarro, J .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (10) :4930-4942

[3] Use of voriconazole in treatment of Scedosporium apiospermum infection:: Case report [J].

Girmenia, C ;

Luzi, G ;

Monaco, M ;

Martino, P .

JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (05) :1436-1438

[4] Scedosporium apiospermum:: changing clinical spectrum of a therapy-refractory opportunist [J].

Guarro, Josep ;

Kantarcioglu, A. Serda ;

Horre, Regine ;

Rodriguez-Tudela, Juan Luis ;

Estrella, Manuel Cuenca ;

Berenguer, Juan ;

De Hoog, G. Sybren .

MEDICAL MYCOLOGY, 2006, 44 (04) :295-327

[5] Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients:: Clinical characteristics and impact of antifungal agent therapy on outcome [J].

Husain, S ;

Muñoz, P ;

Forrest, G ;

Alexander, BD ;

Somani, J ;

Brennan, K ;

Wagener, MM ;

Singh, N .

CLINICAL INFECTIOUS DISEASES, 2005, 40 (01) :89-99

[6]

Ichikawa T, 1997, ACTA DERM-VENEREOL, V77, P172

[7] In vitro activities of new and conventional antifungal agents against clinical Scedosporium isolates [J].

Meletiadis, J ;

Meis, JFGM ;

Mouton, JW ;

Rodriquez-Tudela, JL ;

Donnelly, JP ;

Verweij, PE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (01) :62-68

[8] Primary cutaneous fungal infections in solid organ transplantation: A case series [J].

Miele, PS ;

Levy, CS ;

Smith, MA ;

Dugan, EM ;

Cooke, RH ;

Light, JA ;

Lucey, DR .

AMERICAN JOURNAL OF TRANSPLANTATION, 2002, 2 (07) :678-683

[9] Use of Intralesional Voriconazole for the Treatment of Cutaneous Scedosporium apiospermum Infection [J].

Moreno Azofra, Mariola ;

Pena Somovilla, Jose Luis ;

Carrascosa Porras, Miguel ;

Hurtado Carrillo, Laura ;

Daroca Perez, Rafael .

CLINICAL INFECTIOUS DISEASES, 2010, 51 (02) :255-257

[10] Emerging moulds:: Fusarium, Scedosporium and Zygomycetes in transplant recipients [J].

Nucci, M .

CURRENT OPINION IN INFECTIOUS DISEASES, 2003, 16 (06) :607-612

← 1 2 →