A new sesquiterpene lactone and a new aromatic glycoside from Illicium difengpi

被引：20

作者：

Fang, Lei ^{[1
,2
,3
]}

Wang, Xiao-jing ^{[1
,2
]}

Ma, Shuang-gang ^{[1
,2
]}

Yu, Shi-shan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Shandong Acad Sci, Shandong Anal & Test Ctr, Jinan 250014, Shandong, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2011年 / 1卷 / 03期

关键词：

Illicium difengpi; Sesquiterjaene lactone; Aromatic glycoside; Mosher's method; Anti-inflammatory activities;

D O I：

10.1016/j.apsb.2011.08.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new sesquiterpene lactone (1) and a new aromatic glycoside (2), together with three known compounds (3-5) were isolated from the stem bark of Illicium difengpi K. I. B et K. I. M. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRESIMS, and chemical methods. The absolute configuration of the secondary alcohol in 1 was confirmed by Mosher's method. Compound 2 exhibited significant anti-inflammatory activity with IC50 value of 6.72 mu mol/L. (C) 2011 Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：178 / 183

页数：6

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