MAINTENANCE OF GESTATION IN HYPOPHYSECTOMIZED RATS WITH HIGHLY PURIFIED PITUITARY HORMONES

被引：26

作者：

AHMAD, N

LYONS, WR

PAPKOFF, H

机构：

[1] Department of Anatomy, Hormone Research Laboratory, University of California Medical Center, San Francisco, California

[2] Department of Anatomy, Georgetown University Schools of Medicine and Dentistry, Washington, District of Columbia, 20007, 3900 Reservoir Road, N W.

来源：

ANATOMICAL RECORD | 1969年 / 164卷 / 03期

关键词：

D O I：

10.1002/ar.1091640305

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Pregnancy was maintained in Long‐Evans rats hypophysectomized on day 1 and injected with ovine pituitary gonadotrophins from day 1 through day 11; and also in rats hypophysectomized on day 6 and injected from day 6 through day 11. For successful maintenance until term, no further injections were necessary after day 11. The combination of hormones considered close to optimal was; mammotrophin 2.5 mg; follicle‐stimulating hormone 25 μg; and interstitial cell‐stimulating hormone 5 μg injected daily, subcutaneously. Histological examination of ovaries after this regimen (on day 12) revealed interstitial and luteal tissue that was considered normal for this stage; and follicles that were in some cases larger than expected and occasionally with theca luteinization. The ovaries of the rats allowed to go to term and untreated after day 11 showed follicular and interstitial tissue that had regressed and well‐stimulated corpora lutea. These findings showed no evidence of placental FSH or ICSH‐like hormones; but confirmed earlier reports of a rat placental luteotrophic hormone. Copyright © 1969 Wiley‐Liss, Inc.

引用

页码：291 / &

共 29 条

[11] GONADOTROPIC REQUIREMENTS FOR MAINTENANCE OF PREGNANCY IN HYPOPHYSECTOMIZED RAT [J].

GREENWALD, GS ;

JOHNSON, DC .

ENDOCRINOLOGY, 1968, 83 (05) :1052-+

[12] Ovariectomy and corpus luteum extract studies on rats and ground squirrels [J].

Johnson, GE ;

Challans, JS .

ENDOCRINOLOGY, 1932, 16 (03) :278-284

[13]

KON SK, 1961, MILK MAMMARY GLAN ED, V1, P205

[14]

LI CH, 1961, MILK, V1, P205

[15] AMOUNTS OF INTERSTITIAL CELL-STIMULATING HORMONE AND FOLLICLE-STIMULATING HORMONE REQUIRED FOR FOLLICULAR DEVELOPMENT UTERINE GROWTH AND OVULATION IN HYPOPHYSECTOMIZED RAT [J].

LOSTROH, AJ ;

JOHNSON, RE .

ENDOCRINOLOGY, 1966, 79 (05) :991-&

[16]

Lyons WR, 1943, P SOC EXP BIOL MED, V52, P134, DOI 10.3181/00379727-52-14059

[17]

Lyons WR, 1943, P SOC EXP BIOL MED, V54, P65

[18]

LYONS WR, 1951, ANAT REC, V109, P119

[19] STIMULATION OF ESTROGEN SECRETION FROM NORMAL RAT CORPORA LUTEA BY LUTEINIZING HORMONE [J].

MACDONALD, GJ ;

ARMSTRONG, DT ;

GREEP, RO .

ENDOCRINOLOGY, 1966, 79 (02) :289-+

[20]

NUTTING EF, 1963, DELAYED IMPLANTATION, P233

← 1 2 3 →