A HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF STOBADIN PHARMACOKINETICS IN SERUM

被引：19
|
作者：
SOLTES, L [1 ]
KALLAY, Z [1 ]
BEZEK, S [1 ]
FEDELESOVA, V [1 ]
机构：
[1] INST NATL HLTH, PHARMACOTHERAPY CLIN, CS-83308 BRATISLAVA, CZECHOSLOVAKIA
来源：
BIOPHARMACEUTICS & DRUG DISPOSITION | 1991年 / 12卷 / 01期
关键词：
PHARMACOKINETICS; BIOAVAILABILITY; STOBADIN; GAMMA-CARBOLINE; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY;
D O I：
10.1002/bdd.2510120104
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A high-performance liquid chromatographic method was developed to determine stobadin pharmacokinetics in dog and man. The relative bioavailability of stobadin dipalmitate compared with dihydrochloride was 46.4 per cent in dog. In man peak serum concentrations ranged from 12 to 289 ng ml(-1) after a single oral dose of stobadin dipalmitate (0.79 to 2.5 mg kg(-1).
引用
收藏
页码：29 / 35
页数：7
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