Successful control of opioid-refractory cancer pain with methadone in a patient with advanced oral squamous cell carcinoma: A case report

被引：1

作者：

Sekido, Katsuhisa ^{[1
]}

Tomihara, Kei ^{[1
]}

Horikawa, Hideyo ^{[1
,2
]}

Tachinami, Hidetake ^{[1
]}

Murakami, Nozomu ^{[3
,4
]}

Noguchi, Makoto ^{[1
]}

机构：

[1] Univ Toyama, Grad Sch Med & Pharmaceut Sci Res, Dept Oral & Maxillofacial Surg, 2630 Sugitani, Toyama, Toyama 9300194, Japan

[2] Univ Toyama, Grad Sch Med & Pharmaceut Sci Res, Dept Anesthesiol, 2630 Sugitani, Toyama, Toyama 9300194, Japan

[3] Toyama Univ Hosp, Dept Comprehens Ctr, 2630 Sugitani, Toyama, Toyama 9300194, Japan

[4] Kouseiren Takaoka Hosp, Dept Palliat Care & Surg, 5-10 Eiraku Machi, Takaoka, Toyama 9338555, Japan

来源：

ORAL SCIENCE INTERNATIONAL | 2018年 / 15卷 / 02期

关键词：

Oral squamous cell carcinoma; Cancer pain; Methadone; Opioids; Palliative care;

D O I：

10.1016/S1348-8643(18)30004-1

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Methadone, a synthetic opioid agonist, is used for pain that is refractory to other opioids. However, limited data on its ability to control pain in patients with oral cancer are available. In this study, we present a case of recurrent oral cancer, in which pain was poorly controlled with high-dose oxycodone but successfully controlled with methadone. A 36-year-old male patient was referred to our hospital for the treatment of recurrent oral cancer. His pain no longer responded to increased dosages of oxycodone, and thus oxycodone was switched to methadone. Ultimately, his pain was successfully controlled with methadone throughout his end-of-life stage. (C) 2018 Japanese Stomatological Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：78 / 80

页数：3

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