CHRONIC HYPOXIA AFFECTS PERIPHERAL AND CENTRAL VASOACTIVE INTESTINAL PEPTIDE-LIKE IMMUNOREACTIVITY IN THE RAT

被引：16
|
作者：
PONCET, L [1 ]
DENOROY, L [1 ]
DALMAZ, Y [1 ]
PEQUIGNOT, JM [1 ]
JOUVET, M [1 ]
机构：
[1] UNIV LYON 1,PHYSIOL LAB,CNRS,URA 1195,INSERM,U52,F-69008 LYON,FRANCE
来源：
NEUROSCIENCE LETTERS | 1994年 / 176卷 / 01期
关键词：
HYPOXIA; NEUROPEPTIDE; VASOACTIVE INTESTINAL PEPTIDE; VIP; RADIOIMMUNOASSAY; CHEMOREFLEXE;
D O I：
10.1016/0304-3940(94)90856-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The influence of long-term hypoxia on vasoactive intestinal peptide-like immunoreactivity (VIP-LI) in discrete brain areas and peripheral structures was assessed by RIA. Rats were exposed to normobaric hypoxia (10% O-2 -90% N-2) for 14 days. VIP-LI was significantly increased in carotid bodies of hypoxic animals (204% vs. normoxic animals). On the other hand, VIP-LI was decreased in the anterior pituitary (-68%), suprachiasmatic nuclei (-29%) and periventricular nuclei (-26%). No significant variation in VIP-LI was observed in other peripheral structures and discrete brain areas studied. These results suggest that long-term hypoxia induces alterations in VIP systems implicated in chemoreception, biological rhythms and neuroendocrine functions.
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页码：1 / 4
页数：4
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