MDR1 GENE-EXPRESSION IN PRIMARY COLORECTAL CARCINOMAS

被引：30

作者：

PIRKER, R ^{[1
]}

WALLNER, J ^{[1
]}

GSUR, A ^{[1
]}

GOTZL, M ^{[1
]}

ZOCHBAUER, S ^{[1
]}

SCHEITHAUER, W ^{[1
]}

DEPISCH, D ^{[1
]}

机构：

[1] GEN HOSP,DEPT SURG,A-2700 NEUSTADT,AUSTRIA

来源：

BRITISH JOURNAL OF CANCER | 1993年 / 68卷 / 04期

关键词：

D O I：

10.1038/bjc.1993.411

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of the MDR1 gene, a multidrug resistance gene, was prospectively determined in 113 primary colorectal carcinoma specimens and correlated with clinical data including survival durations of the patients. MDR1 RNA was detected in 65% of the carcinomas. No expression of the MDR2 gene was seen. MDR1 gene expression was independent of age and sex of the patients, size and histologic grading of the tumour, lymph node involvement and distant metastasis. Kaplan-Meier analysis revealed that the durations of both relapse-free survival and overall survival were not different between patients with MDR1 RNA positive tumours and those with MDR1 RNA negative tumours.

引用

收藏

页码：691 / 694

页数：4

相关论文

共 27 条

[1] DETECTION OF P-GLYCOPROTEIN IN OVARIAN-CANCER - A MOLECULAR MARKER ASSOCIATED WITH MULTIDRUG RESISTANCE [J].

BELL, DR ;

GERLACH, JH ;

KARTNER, N ;

BUICK, RN ;

LING, V .

JOURNAL OF CLINICAL ONCOLOGY, 1985, 3 (03) :311-315

[2]

CAMPOS L, 1992, BLOOD, V79, P473

[3] IMMUNOHISTOCHEMICAL DETECTION OF P-GLYCOPROTEIN - PROGNOSTIC CORRELATION IN SOFT-TISSUE SARCOMA OF CHILDHOOD [J].

CHAN, HSL ;

THORNER, PS ;

HADDAD, G ;

LING, V .

JOURNAL OF CLINICAL ONCOLOGY, 1990, 8 (04) :689-704

[4] P-GLYCOPROTEIN EXPRESSION AS A PREDICTOR OF THE OUTCOME OF THERAPY FOR NEUROBLASTOMA [J].

CHAN, HSL ;

HADDAD, G ;

THORNER, PS ;

DEBOER, G ;

LIN, YP ;

ONDRUSEK, N ;

YEGER, H ;

LING, V .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (23) :1608-1614

[5] DRUG-RESISTANCE IN MULTIPLE-MYELOMA AND NON-HODGKINS LYMPHOMA - DETECTION OF P-GLYCOPROTEIN AND POTENTIAL CIRCUMVENTION BY ADDITION OF VERAPAMIL TO CHEMOTHERAPY [J].

DALTON, WS ;

GROGAN, TM ;

MELTZER, PS ;

SCHEPER, RJ ;

DURIE, BGM ;

TAYLOR, CW ;

MILLER, TP ;

SALMON, SE .

JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (04) :415-424

[6] EXPRESSION OF A MULTIDRUG-RESISTANCE GENE IN HUMAN-TUMORS AND TISSUES [J].

FOJO, AT ;

UEDA, K ;

SLAMON, DJ ;

POPLACK, DG ;

GOTTESMAN, MM ;

PASTAN, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (01) :265-269

[7] INTRINSIC DRUG-RESISTANCE IN HUMAN-KIDNEY CANCER IS ASSOCIATED WITH EXPRESSION OF A HUMAN MULTIDRUG-RESISTANCE GENE [J].

FOJO, AT ;

SHEN, DW ;

MICKLEY, LA ;

PASTAN, I ;

GOTTESMAN, MM .

JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (12) :1922-1927

[8] P-GLYCOPROTEIN IN HUMAN SARCOMA - EVIDENCE FOR MULTIDRUG RESISTANCE [J].

GERLACH, JH ;

BELL, DR ;

KARAKOUSIS, C ;

SLOCUM, HK ;

KARTNER, N ;

RUSTUM, YM ;

LING, V ;

BAKER, RM .

JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (09) :1452-1460

[9] EXPRESSION OF A MULTIDRUG RESISTANCE GENE IN HUMAN CANCERS [J].

GOLDSTEIN, LJ ;

GALSKI, H ;

FOJO, A ;

WILLINGHAM, M ;

LAI, SL ;

GAZDAR, A ;

PIRKER, R ;

GREEN, A ;

CRIST, W ;

BRODEUR, GM ;

LIEBER, M ;

COSSMAN, J ;

GOTTESMAN, MM ;

PASTAN, I .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (02) :116-124

[10]

GOTTESMAN MM, 1988, J BIOL CHEM, V263, P12163