PREVALENCE OF LEFT-VENTRICULAR SYSTOLIC DYSFUNCTION IN DUCHENNE MUSCULAR-DYSTROPHY - AN ECHOCARDIOGRAPHIC STUDY

被引:69
|
作者
DEKERMADEC, JM
BECANE, HM
CHENARD, A
TERTRAIN, F
WEISS, Y
机构
[1] Department of Internal Medicine and Myopathy, Meaux General Hospital Meaux
关键词
D O I
10.1016/0002-8703(94)90672-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The prevalence and hemodynamic consequences of regional wall motion abnormalities (RWMA) were evaluated in 84 advanced-stage Duchenne muscular dystrophy (DMD) patients who underwent echocardiographic and systolic time interval (STI) examination. A satisfactory echocardiogram was obtained in 72 patients who were divided into two groups: group I (33 patients) had normal wall motion or minor changes, and group II (39 patients) had akinetic and/or dyskinetic areas. In group II, 15 patients had ventricular dilation; 8 of the 15 had a history of cardiac failure and 4 died during the study. Wall motion index (WMI), end-diastolic volume (EDV), and STI values increased significantly from group I to group II. In the whole group, a strong correlation was found between WMI and STI ratios. This study demonstrates a high prevalence of RWMA and supports the viewpoint that RWMA, consequences of the myopathic process, result in progressive left ventricular dilation, heart failure, and cardiac death.
引用
收藏
页码:618 / 623
页数:6
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