EFFECT OF ALLOXAN-INDUCED DIABETES ON ACETYLCHOLINESTERASE ACTIVITY FROM DISCRETE AREAS OF RAT-BRAIN

被引：15
|
作者：
LAKHMAN, SS [1 ]
KAUR, G [1 ]
机构：
[1] GURU NANAK DEV UNIV, DEPT ZOOL, NEUROENDOCRINOL & NEUROCHEM LAB, AMRITSAR 143005, PUNJAB, INDIA
来源：
NEUROCHEMISTRY INTERNATIONAL | 1994年 / 24卷 / 02期
关键词：
D O I：
10.1016/0197-0186(94)90102-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of experimental diabetes induced in rats was examined in brain areas like the septum, medial preoptic area, median eminence-arcuate region, amygdala, thalamus, hippocampus, pens and medulla. In all the areas studied, acute hyperglycemia caused an increase in the activity of acetylcholinesterase, the degradative enzyme of cholinergic system, whereas insulin administration reversed this effect. These findings suggest that the dysfunction of cholinergic system may also be involved in the diabetes associated CNS complications.
引用
收藏
页码：159 / 163
页数：5
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