BIOLOGICAL-ACTIVITY OF AN ANTIBIOTIC PUROMYCIN - A THEORETICAL-STUDY

被引：2
作者：
OJHA, RP
SANYAL, NK
机构：
[1] Biophysics Unit, Department of Physics, University of Gorakhpur, Gorakhpur
来源：
JOURNAL OF BIOSCIENCES | 1990年 / 15卷 / 04期
关键词：
ANTIBIOTICS; INTERACTION ENERGY; PUROMYCIN;
D O I：
10.1007/BF02702683
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Puromycin is known to be an anti-tumor agent. Evaluation of interaction energy of this molecule with nucleic acid bases and base pairs has been performed using quantum-mechanical perturbation technique. Both in-plane and stacking energies have been evaluated. These energy values along with their sites of association have been compared with the standard values during transcription process. The results have been examined in the light of their biological significance.
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页码：417 / 425
页数：9
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