Role of proprotein convertase subtilisin/kexin type 9 inhibitors in patients with coronary artery disease undergoing percutaneous coronary intervention

被引:7
作者
Navarese, Eliano P. [1 ,2 ,3 ]
Kolodziejczak, Michalina [1 ,2 ]
Petrescu, Aniela [4 ]
Wernly, Bernhard [5 ]
Lichtenauer, Michael [5 ]
Lauten, Alexander [6 ]
Buffon, Antonino [7 ]
Wanha, Wojciech [8 ]
Pestrichella, Vincenzo [9 ]
Sardella, Gennaro [10 ]
Contegiacomo, Gaetano [11 ]
Tantry, Udaya [3 ]
Bliden, Kevin [3 ]
Kubica, Jacek [2 ]
Gurbel, Paul A. [3 ]
机构
[1] SIRIO Med Cardiovasc Res Network, Fairfax, VA USA
[2] Nicolaus Copernicus Univ, Ludwik Rydygier Coll Med, Cardiovasc Inst, Bydgoszcz, Poland
[3] Inova Heart & Vasc Inst, Inova Ctr Thrombosis Res & Drug Dev, Fairfax, VA 22042 USA
[4] Univ Ziekenhuis Gasthuisberg Leuven, Leuven, Belgium
[5] Paracelsus Med Univ Salzburg, Dept Cardiol, Clin Internal Med 2, Salzburg, Austria
[6] Charite Univ Med Berlin, Univ Heart Ctr, German Ctr Cardiovasc Res DZHK, Dept Cardiol, Berlin, Germany
[7] Catholic Univ Med Sch, Inst Cardiol, Rome, Italy
[8] Med Univ Silesia, Sch Hlth Sci, Dept Cardiol, Katowice, Poland
[9] Mater Dei Hosp, Dept Cardiol, Intervent Cardiol Unity, Bari, Italy
[10] Sapienza Univ Rome, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Rome, Italy
[11] Mater Dei Hosp, Dept Cardiol, Bari, Italy
关键词
PCSK9; inhibitor; Pci; coronary artery disease; percutaneous coronary intervention;
D O I
10.1080/14779072.2018.1474099
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Although novel therapies have improved outcomes in PCI patients, a sizeable number of patients still remain at high cardiovascular risk for recurrent event. There is therefore an unmet need for novel therapies that can improve clinical outcomes, with an associated satisfactory safety profile. Proprotein convertase subtilisin/kexin type 9 (PCSK9) enzyme is a novel lipid-lowering target with a potential to impact high-cardiovascular risk populations including patients with coronary artery disease (CAD), undergoing the percutaneous coronary intervention (PCI). A number of canonical and non-canonical pathways of PCSK9 action, including inflammation and platelet activation, as well as their inhibition, are undergoing intense investigation. Areas covered: This review will discuss the currently available evidence on PCSK9 inhibitors, pathways of PCSK9 enzyme action and results or its inhibition, the potential role of PCSK9 inhibitors in specific populations undergoing PCI, and completed and ongoing studies in patients with CAD. Expert commentary: PCSK9 inhibitors clinical outcomes in high risk cardiovascular disease patients and have the potential to function as powerful adjunctive therapy in patients undergoing PCI by a twofold mechanism on both lipid lowering and platelet/inflammation pathways.
引用
收藏
页码:419 / 429
页数:11
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