INTERACTION OF CHOLINESTERASE REACTIVATORS WITH CHOLESTEROL MONOLAYERS AT THE AIR-WATER-INTERFACE

被引:0
|
作者
OLTEANU, M [1 ]
CINTEZA, O [1 ]
MIRCIOU, C [1 ]
机构
[1] CLIN HOSP FUNENI,BUCHAREST,ROMANIA
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D O I
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中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The present study deals with the effects of cholinesterase reactivator oximes (Pralidoxime and Obidoxime) dissolved in aqueous subphase on the behavior of the cholesterol monolayers at the air-water interface. The surface pressure-area isotherms show some interactions between cholesterol and oximes. The values obtained for two-dimensional virial coefficient B2, cohesive force surface pressure PI(co) and dispersion forces C2 indicated an in-plane interaction among hydrophilic heads of cholesterol and drug molecules.
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页码:787 / 793
页数:7
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