INVOLVEMENT OF NITRIC-OXIDE IN BASAL AND INTERLEUKIN-1-BETA-INDUCED CRH AND ACTH RELEASE IN-VITRO

被引：44
作者：
BRUNETTI, L
PREZIOSI, P
RAGAZZONI, E
VACCA, M
机构：
[1] UNIV CATTOLICA SACRO CUORE, DEPT PHARMACOL, I-00168 ROME, ITALY
[2] UNIV G DANNUNZIO, DEPT PHARMACOL, I-66100 CHIETI, ITALY
来源：
LIFE SCIENCES | 1993年 / 53卷 / 13期
关键词：
D O I：
10.1016/0024-3205(93)90267-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
N(G)-Nitro-L-arginine, an inhibitor of nitric oxide synthase, does not influence CRH basal release but is able to modify ACTH basal secretion and to block interleukin-1beta-induced CRH and ACTH release from rat hypothalamic and anterior pituitary cell cultures in vitro. The data suggest a different involvement of NO at hypothalamic and pituitary level.
引用
收藏
页码：PL219 / PL222
页数：4
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