STAGE-SPECIFIC ADHESION OF LEISHMANIA PROMASTIGOTES TO THE SANDFLY MIDGUT

被引：206

作者：

PIMENTA, PFP

TURCO, SJ

MCCONVILLE, MJ

LAWYER, PG

PERKINS, PV

SACKS, DL

机构：

[1] NIAID,PARASIT DIS LAB,BLDG 4,ROOM 126,BETHESDA,MD 20892

[2] WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307

[3] UNIV KENTUCKY,MED CTR,DEPT BIOCHEM,LEXINGTON,KY 40536

[4] UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND

来源：

SCIENCE | 1992年 / 256卷 / 5065期

关键词：

D O I：

10.1126/science.1615326

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although leishmaniasis is transmitted to humans almost exclusively by the bite of infected phlebotomine sandflies, little is known about the molecules controlling the survival and development of Leishmania parasites in their insect vectors. Adhesion of Leishmania promastigotes to the midgut epithelial cells of the sandfly was found to be an inherent property of noninfective-stage promastigotes, which was lost during their transformation to metacyclic forms, thus permitting the selective release of infective-stage parasites for subsequent transmission by bite. Midgut attachment and release was found to be controlled by specific developmental modifications in terminally exposed saccharides on lipophosphoglycan, the major surface molecule on Leishmania promastigotes.

引用

页码：1812 / 1815

页数：4

共 26 条

[1] CELL SUBSTRATE ADHESION DURING TRYPANOSOMA-CRUZI DIFFERENTIATION [J].