NEW 2-ARYLIMINOIMIDAZOLIDINES .2. SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF 2-(BIPHENYLIMINO)IMIDAZOLIDINES

被引：4
|
作者：
TANIGUCHI, K [1 ]
KATSURA, Y [1 ]
UEDA, I [1 ]
MATSUO, M [1 ]
机构：
[1] FUJISAWA PHARMACEUT CO LTD, NEW DRUG RES LABS, 1-6 2 CHOME KASHIMA, YODOGAWA KU, OSAKA 532, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 01期
关键词：
HYPOTENSIVE ACTIVITY; 2-ARYLIMINOIMIDAZOLIDINE; 2-(BIPHENYLIMINO)IMIDAZOLIDINE; CLONIDINE; STRUCTURE-ACTIVITY RELATIONSHIP; ACTION DURATION;
D O I：
10.1248/cpb.40.240
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
For improvement of the duration of action of FR35447 (I), 2-(biphenylimino)imidazolidines (III) were synthesized and their hypotensive activity was tested against conscious normotensive rats. 2-(4'-Fluoro-[1,1'-biphenyl]-2-ylimino)imidazolidine (III 1) exhibited superior hypotensive potency and was comparable to clonidine (II) in its duration of action. The structure-activity relationships of III are also described.
引用
收藏
页码：240 / 244
页数：5
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