RAT MODEL OF EXPERIMENTAL BACTERIAL PROSTATITIS

被引：29

作者：

NICKEL, JC ^{[1
]}

OLSON, ME ^{[1
]}

COSTERTON, JW ^{[1
]}

机构：

[1] UNIV CALGARY,DEPT BIOL SCI,CALGARY T2N 1N4,ALBERTA,CANADA

来源：

INFECTION | 1991年 / 19卷

关键词：

D O I：

10.1007/BF01643681

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A reproducible rat model of chronic bacterial prostatitis was developed employing a defined bacterial pathogen to study the pathophysiology of acute and chronic bacterial prostatitis. The progression of inflammation and its consequences following the retrograde introduction of bacteria through the acute and finally the chronic stages of prostatitis can be documented with microbiological, histological, ultrastructural and immunologic data. This model has many striking similarities to the natural history of human chronic bacterial prostatitis and further microbiological, antimicrobial and immune modulation or manipulation of this model should help us to further delineate the pathogenic mechanisms involved in this chronic infective disease.

引用

页码：S126 / S130

页数：5

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