EFFECTS OF GROWTH-HORMONE AND ESTROGEN ON RAT ANGIOTENSINOGEN QUANTIFIED BY AN ENZYME-LINKED-IMMUNOSORBENT-ASSAY

被引：1

作者：

KARLSSON, R

STIGBRAND, T

OSCARSSON, J

EDEN, S

BOUHNIK, J

CELIO, M

VONSCHOULTZ, B

机构：

[1] UMEA UNIV, DEPT PHYSIOL CHEM, S-90187 UMEA, SWEDEN

[2] GOTHENBURG UNIV, DEPT PHYSIOL, S-40033 GOTHENBURG, SWEDEN

[3] INSERM, U36, F-75005 PARIS, FRANCE

[4] UNIV KIEL, INST ANAT, W-2300 KIEL 1, GERMANY

[5] KAROLINSKA HOSP, DEPT OBSTET & GYNECOL, S-10401 STOCKHOLM 60, SWEDEN

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE | 1992年 / 14卷 / 03期

关键词：

ANGIOTENSINOGEN; GROWTH HORMONE; SECRETORY PATTERN; ENZYME LINKED IMMUNOSORBENT ASSAY;

D O I：

10.3109/10641969209036206

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An enzyme linked immunosorbent assay for rat angiotensinogen was developed based on one monoclonal antibody with high affinity for angiotensinogen and des-angiotensin 1-angiotensinogen and rabbit polyclonal antibodies for angiotensinogen was developed. Serum levels of angiotensinogen were lower in female than in male rats but increased significantly after hypophysectomy. Estrogen substitution after hypophysectomy had no further stimulatory or inhibitory influence. In hypophysectomized animals continuous and intermittent growth hormone administration had clearly different effects. The results indicate that the sexually dimorphic secretion of growth hormone is involved in the regulation of circulating angiotensinogen concentrations in the rat.

引用

页码：551 / 563

页数：13

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